½üÈÕ£¬¹ú¼ÊÖøÃûÆÚ¿¯Progress in Lipid Research£¨IF16.195£¬ÖпÆÔº´óÀà1ÇøTop£©ÔÚÏß·¢±íËÄ´¨Å©Òµ´óѧbifa·½Õý·æ½ÌÊÚ¿ÎÌâ×éÌâΪBile acids and their receptors in regulation of gut health and diseasesµÄÂÛÎÄ¡£¸Ã¿ÎÌâ×éÒ»Ö±ÖÂÁ¦ÓÚÖ¬ÀàÓªÑø¼°µ¨Ö­Ëá´úлÓ뽡¿µÑо¿¡£

ÂÛÎÄϵͳ²ûÊöÁ˽üÄêÀ´ÔÚÖ¬ÖÊÑо¿ÁìÓò±¸ÊܹØ×¢µÄµ¨Ö­Ëá¼°ÆäÊÜÌåÔÚ³¦µÀ½¡¿µÖеĵ÷½Ú×÷Óü°»úÖÆ¡£Ö÷Òª´Óµ¨Ö­ËáÉúÀí£¨ºÏ³ÉÓë´úл£¬³¦¸ÎÑ­»·¡¢Î¢ÉúÎïת»¯£©¡¢µ¨Ö­ËáÊÜÌ壨ºËÊÜÌ塢ĤÊÜÌ壩¡¢µ¨Ö­Ëá¼°ÆäÊÜÌåÔÚ³¦µÀÉúÀíºÍÃâÒßÖеÄ×÷Ó㨳¦ÉÏƤϸ°ûÔöÖ³ÓëµòÍö¡¢³¦ÉÏƤÆÁÕϹ¦ÄÜ¡¢³¦µÀÑ×Ö¢ÓëÃâÒߣ©¡¢µ¨Ö­Ëá¼°ÆäÊÜÌåÔÚ³¦µÀʧµ÷Öеĵ÷½Ú×÷Ó㨴ó³¦Ñס¢½áÖ±³¦°©¡¢µ¨Ö­Ëḹк£©µÈ·½Ã棬½éÉÜÁ˸ÃÍŶӽüÄêÀ´ÔÚµ¨Ö­ËáÁìÓòµÄ¶àƪÑо¿±¨µÀ¡£

ÂÛÎĵÚÒ»×÷ÕßΪÎÒУ2018½ì²©Ê¿ÁÖÉ­£¨µ¼Ê¦·½Õý·æ½ÌÊÚ£©£¬Æ䲩ʿÂÛÎľ۽¹µ¨Ö­Ëá¼°ÆäÊÜÌå¶Ô×ÐÖí³¦µÀ½¡¿µµÄ×÷Óü°µ÷¿ØÑо¿£¬ÂÛÎÄÏà¹ØÄÚÈÝÏȺóÔÚ¹ú¼ÊÉúÀíѧ֪ÃûÆÚ¿¯Am J Physiol Gastrointest Liver Physiol£¬Å©ÁÖÀà1ÇøTopÆÚ¿¯J Agri Food Chem£¬Ò½Ñ§ÀàTopÆÚ¿¯Br J Nutr·¢±í£¬ÏÖÈÎÖ°Óڹ㶫ʡũҵ¿ÆѧԺ£¬¼ÌÐø´Óʵ¨Ö­Ëá¼°ÆäÊÜÌåÓ볦µÀ½¡¿µÑо¿£¬²¢»ñ×¼¹ú¼Ò×ÔÈ»¿ÆѧÇàÄêÏîÄ¿×ÊÖú¡£

¾ÝϤ£¬¡°ÈÑÉïÆÚ¸ÎÄÚµ¨Ö­ÓÙ»ýÖ¢¡±ÊÇ»³Ôи¾Å®×îΪ³£¼ûµÄ¸ÎÔ༲²¡£¬»áÔì³ÉÌ¥¶ùÔç²ú¡¢ËÀÍöµÈ²»Á¼ºó¹û£¬¶øÇÒ»³Ë«°ûÌ¥µÄ¸¾Å®µ¨Ö­ÓÙ»ýÖ¢µÄ·¢ÉúÂÊÔ¶¸ßÓÚµ¥°ûÌ¥¸¾Å®¡£¼øÓÚÖíºÍÈË»ùÒò¡¢½âÆÊÉúÀí½á¹¹¼°ÉúÀí´úлµÄ¸ß¶ÈÏàËÆÐÔ£¬·½Õý·æ½ÌÊÚ¿ÎÌâ×éÂÊÏÈÒÔÈÑÉïĸÖíΪģÐÍ£¬Ê״νÒʾµ¨Ö­ËáÎÈ̬ʧºâÊÇÈÑÉïºóÆÚÌ¥ÖíËÀÍöµÄÖØÒªÔ­Òò£¬²¢·Ö±ðÒÔTPN£¨È«³¦ÍâÓªÑø£©¡¢SBS£¨³¦¶ÎÇгý£©¡¢SUN£¨ÌìȻӪÑøȱ·¦£©×ÐÖí¼°Ï¸°ûΪģÐÍ£¬ÏµÍ³²ûÊÍÁ˵¨Ö­ËáÊÜÌåFXR£¨·¨ÄáËØXÊÜÌ壩ºÍTGR5£¨Gµ°°×żÁªµ¨Ö­ËáÊÜÌå1£©¶Ôά³Öµ¨Ö­ËáÎÈ̬ºÍ³¦¸Î½¡¿µµÄ»úÖÆ£¬ÎªÌá¸ßÌ¥Öí´æ»îÕÒµ½ÁËеÄÍ»ÆÆ¿Ú£¬¶Ô¸ÄÉÆÈ˵Ľ¡¿µÉúÖ³¾ßÓÐÖØÒªµÄ²Î¿¼¼ÛÖµ¡£ÒÔÉÏÑо¿µÃµ½Á˹ú¼Ò×ÔÈ»¿Æѧ»ù½ð¡¢¹ú¼ÒÁôѧ»ù½ðµÈÏîÄ¿×ÊÖú£¬ÀÛ¼ÆÔÚHepatology£¬Am J Physiol Gastrointest Liver Physiol£¬J Agri Food Chem£¬J Lipid ResµÈ¹ú¼ÊÖªÃûÆÚ¿¯·¢±íѧÊõÂÛÎÄ10ƪ£¬ÅàÑø±ÏÒµ²©Ê¿2Ãû¡¢Ë¶Ê¿2Ãû¡£

Ô­ÎÄÁ´½Ó£º

Sen Lin, Sutian Wang, Peng Wang, Cuiming Tang, Zhenjiang Wang, Lian Chen, Guoqing Luo, Hong Chen, Yuntao Liu, Bin Feng, De Wu, Douglas G. Burrin, Zhengfeng Fang*. Bile acids and their receptors in regulation of gut health and diseases. Progress in Lipid Research.2023.https://doi.org/10.1016/j.plipres.2022.101210